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KMID : 0369819750050040424
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Jorunal of Korean Pharmaceutical Sciences
1975 Volume.5 No. 4 p.424 ~ p.431
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The Effects of Proteolytic Enzyme on the Absorption and Excretion of Pyrazinamide
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이진환/Lee JH
최준식/Choi JS
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Abstract
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This paper attempts to investigate the effect of proteolytic enzyme on the absorption and excretion of pyrazinamide. The rat small intestinal absorption of pyrazinamide in the presence of proteolytic enzyme such as chymotrypsin and compounding enzyme (chymotrypsin and trypsin) are increasingly absorbed, but in the trypsin are similar to that of control. Blood levels of pyrazinamide after rabbit's duodenum injection are significantly enhenced to correspond to 112-120% by proteolytic enzymes concentration respectively, but both on the high concentration of chymotrypsin and the low concentration of trypsin are insignificantly enhenced. Proteolytic enzymes do not give the effect on clearance of pyrazinamide. Proteolytic enzymes give the effect on absorption of pyrazinamide, but do not give the effect on excretion of pyrazinamide.
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KEYWORD
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